Steroids and derivatives
Selleck Chemical LLC Dexamethasone 21-phosphate
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects
Selleck Chemical LLC Dexamethasone 21-phosphate
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects
Selleck Chemical LLC Prednisone acetate
Prednisone acetate (Betapar Cortan Deltasone Fernisone Meticorten Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties
Selleck Chemical LLC Hydrocortisone hemisuccinate
Hydrocortisone hemisuccinate (A-hydrocort Hydrocortisone 21-hemisuccinate) a physiological glucocorticoid with anti-inflammatory properties is an inhibitor of proinflammatory cytokine with IC50 of 6 7 M and 21 4 M for Interleukin-6 (IL-6) and IL-3 respectively
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 10mM (in 1mL DMSO)
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions
Medchemexpress LLC HY-N0554 5mg Medchemexpress, Escin IA CAS:123748-68-5 Purity:>98%
Medchemexpress, HY-N0554 5mg Escin IA CAS:123748-68-5 Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-A0020 1mg Medchemexpress, Eldecalcitol CAS:104121-92-8 Purity:>98%
Medchemexpress, HY-A0020 1mg Eldecalcitol CAS:104121-92-8 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences Escin | Purity: 98% | Mol Wt: 1131.19 | CAS No: 6805-41-0 | MDL No: MFCD00130460 | 500mg
Escin | Purity: 98% | Mol Wt: 1131.19 | CAS No: 6805-41-0 | MDL No: MFCD00130460 | 500mg
Apexbio Technology LLC Cyproterone Acetate 427-51-0 250mg
Cyproterone Acetate (CAS 427-51-0) is a small-molecule antagonist targeting the androgen receptor (AR) It is designed to inhibit AR activation thereby suppressing androgen-mediated cellular signaling Cyproterone Acetate exerts its biological activity primarily through competitive binding to AR displacing endogenous androgen ligands and blocking receptor activation and downstream signaling In experimental assays Cyproterone Acetate demonstrates AR inhibition with an IC50 value of approximately 7 1 nM At higher concentrations (EC50 around 4 0 M) it may also exhibit partial agonist activity on the AR pathway Based on these pharmacological properties Cyproterone Acetate holds research potential in studies of androgen-dependent biological processes AR signaling mechanisms and hormone-sensitive pathologies such as prostate cancer or androgen-related metabolic conditions
eMolecules Ambeed / 136-Trihydroxy-7-methoxy-28-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one / 1mg / 761012452 / A161573 / / 6147-11-1 / MFCD00135200 / 410.466 / C24H26O6
Ambeed / 136-Trihydroxy-7-methoxy-28-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one / 1mg / 761012452 / A161573 / / 6147-11-1 / MFCD00135200 / 410.466 / C24H26O6
Cayman Chemical GlycocholIc AcId 1g
A glycine-conjugated form of cholic acid; has roles in the emulsification of fats; reduces expression of the gene encoding FXR and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells at 1.6 μmol/ml; increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells at 250 μM, as well as decreases expression of the genes encoding MDR1, MRP1, and MRP2 when used alone or in combination with epirubicin; increases absorption of epirubicin into everted sacs of rat ileum and jejunum at 250 μM; bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases; serum levels are elevated in patients with hepatocellular carcinoma compared with healthy individuals